Systemic sarcoidosis with unique vulvar involvement.

Systemic SarcoidosisWith Unique Vulvar Involvement Sarcoidosis is a complex, multisystem disease with an unclear cause.1 Research suggests that the pathogeneticmechanism of sarcoidosis is dysregulation of the immune system in individuals with a genetic predisposition who are subsequently exposed to inciting environmental agents.2 Cutaneous sarcoidosis is often one of the earliest clinical signs of the disease and can be divided into 2 subclasses: specific and nonspecific lesions. Specific lesions are characterizedbygranulomas identifiedhistologically and includemacules, papules, plaques, annular lesions, lupus pernio, infiltration of scars, and subcutaneous nodules.3 Alternatively, nonspecific sarcoid lesions, including erythema nodosum, prurigo, or calcifications, are reactive inflammatory processes.3